| 19. Round | 15/01/2022 | 1. FC Nürnberg | - | SC Paderborn 07 | 1:2 | ||||
| 20. Round | 22/01/2022 | SC Paderborn 07 | - | Werder Bremen | 3:4 |  |
|||
| 21. Round | 05/02/2022 | FC St. Pauli | - | SC Paderborn 07 | 2:2 | ||||
| 22. Round | 12/02/2022 | SC Paderborn 07 | - | Dynamo Dresden | 0:0 | ||||
| 23. Round | 18/02/2022 | FC Schalke 04 | - | SC Paderborn 07 | 2:0 | ||||
| 24. Round | 25/02/2022 | SC Paderborn 07 | - | Erzgebirge Aue | 3:3 | ||||
| 25. Round | 04/03/2022 | Holstein Kiel | - | SC Paderborn 07 | 3:4 | |
|||
| 26. Round | 12/03/2022 | SC Paderborn 07 | - | Fortuna Düsseldorf | 1:1 | ||||
| 27. Round | 20/03/2022 | Jahn Regensburg | - | SC Paderborn 07 | 1:0 | ||||
| 28. Round | 02/04/2022 | Hamburger SV | - | SC Paderborn 07 | 1:2 | ||||
| 29. Round | 10/04/2022 | SC Paderborn 07 | - | Karlsruher SC | 2:2 | ||||
| 30. Round | 17/04/2022 | FC Ingolstadt 04 | - | SC Paderborn 07 | 0:1 | |
|||
| 31. Round | 24/04/2022 | SC Paderborn 07 | - | Hannover 96 | 3:0 | |
 |
||
| 32. Round | 30/04/2022 | Hansa Rostock | - | SC Paderborn 07 | 0:0 | ||||
| 33. Round | 06/05/2022 | SC Paderborn 07 | - | SV Sandhausen | 2:0 | |
|||
| 34. Round | 15/05/2022 | SV Darmstadt 98 | - | SC Paderborn 07 | 3:0 |
Germany