| 1. Round | 29/08/2021 | FCE Rheine | - | SC Paderborn 07 II | 1:0 |  |
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| 2. Round | 05/09/2021 | SC Paderborn 07 II | - | TSG Sprockhövel | 4:0 |  |
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| 3. Round | 12/09/2021 | Hammer SpVg | - | SC Paderborn 07 II | 1:3 | ||||
| 4. Round | 19/09/2021 | SC Paderborn 07 II | - | Sportfreunde Siegen | 3:1 | ||||
| 12. Round | 14/11/2021 | Westfalia Herne | - | SC Paderborn 07 II | 1:2 | ||||
| 13. Round | 20/11/2021 | SC Paderborn 07 II | - | Westfalia Rhynern | 0:3 | ||||
| 14. Round | 25/11/2021 | Holzwickeder SC | - | SC Paderborn 07 II | 0:6 | ||||
| 15. Round | 05/12/2021 | SC Paderborn 07 II | - | ASC 09 Dortmund | 3:1 | ||||
| 11. Round | 08/12/2021 | SC Paderborn 07 II | - | RSV Meinerzhagen | 5:1 | |
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| 16. Round | 12/12/2021 | SG Finnentrop/Bamenohl | - | SC Paderborn 07 II | 2:2 | ||||
| 19. Round | 13/03/2022 | SC Paderborn 07 II | - | TuS Ennepetal | 2:0 | ||||
| 21. Round | 26/03/2022 | SC Paderborn 07 II | - | SG Wattenscheid 09 | 3:0 | ||||
| 20. Round | 30/03/2022 | SV Schermbeck | - | SC Paderborn 07 II | 1:2 |
Germany