| 15. Round | 07/11/1980 | SC Freiburg | - | FC 08 Homburg | 0:1 | ||||
| 16. Round | 14/11/1980 | FC 08 Homburg | - | Hessen Kassel | 0:0 | ||||
| 17. Round | 27/11/1980 | FC Augsburg | - | FC 08 Homburg | 3:5 |  |
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| 18. Round | 05/12/1980 | FC 08 Homburg | - | VfB Eppingen | 1:0 | ||||
| 19. Round | 12/12/1980 | Eintracht Trier | - | FC 08 Homburg | 2:0 | ||||
| 21. Round | 09/01/1981 | FC 08 Homburg | - | VfR Bürstadt | 1:1 | ||||
| 22. Round | 16/01/1981 | Stuttgarter Kickers | - | FC 08 Homburg | 3:1 | |
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| 23. Round | 23/01/1981 | FC 08 Homburg | - | ESV Ingolstadt | 2:1 | ||||
| 24. Round | 06/02/1981 | Kickers Offenbach | - | FC 08 Homburg | 2:0 | ||||
| 25. Round | 13/02/1981 | FC 08 Homburg | - | Freiburger FC | 2:0 | ||||
| 27. Round | 05/03/1981 | FC 08 Homburg | - | SpVgg Bayreuth | 1:3 | ||||
| 28. Round | 12/03/1981 | SpVgg Fürth | - | FC 08 Homburg | 1:1 | ||||
| 29. Round | 20/03/1981 | FC 08 Homburg | - | 1. FC Saarbrücken | 2:2 | ||||
| 30. Round | 26/03/1981 | FC 08 Homburg | - | Waldhof Mannheim | 2:1 | ||||
| 31. Round | 03/04/1981 | Wormatia Worms | - | FC 08 Homburg | 0:0 |
Germany