| 1. Round | 15/08/2021 | 1899 Hoffenheim II [Women] | - | SV Henstedt-Ulzburg [Women] | 4:1 | ||||
| 2. Round | 29/08/2021 | SV Henstedt-Ulzburg [Women] | - | Bayern München II [Women] | 3:1 |  |
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| 3. Round | 05/09/2021 | Eintracht Frankfurt II [Women] | - | SV Henstedt-Ulzburg [Women] | 6:1 | ||||
| 4. Round | 12/09/2021 | SV Henstedt-Ulzburg [Women] | - | SV Meppen [Women] | 1:7 | |
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| 6. Round | 10/10/2021 | SV Henstedt-Ulzburg [Women] | - | Borussia Bocholt [Women] | 2:4 | |
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| 5. Round | 24/10/2021 | SG 99 Andernach [Women] | - | SV Henstedt-Ulzburg [Women] | 3:1 | ||||
| 8. Round | 07/11/2021 | SV Henstedt-Ulzburg [Women] | - | FC Ingolstadt 04 [Women] | 1:5 | ||||
| 9. Round | 14/11/2021 | 1. FC Nürnberg [Women] | - | SV Henstedt-Ulzburg [Women] | 2:0 | ||||
| 10. Round | 21/11/2021 | SV Henstedt-Ulzburg [Women] | - | FSV Gütersloh 2009 [Women] | 2:5 | ||||
| 12. Round | 12/12/2021 | MSV Duisburg [Women] | - | SV Henstedt-Ulzburg [Women] | 4:2 |
Germany