| 1. Round | 30/08/1980 | ASG Vorwärts Dessau | - | BSG Chemie Leipzig | 1:2 |  |
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| 10. Round | 15/11/1980 | Chemie Schönebeck | - | BSG Chemie Leipzig | 1:3 | ||||
| 11. Round | 22/11/1980 | BSG Chemie Leipzig | - | BSG Stahl Nordwest Leipzig | 4:3 | |
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| 12. Round | 29/11/1980 | BSG Chemie Leipzig | - | ASG Vorwärts Dessau | 1:3 | ||||
| 13. Round | 06/12/1980 | BSG Chemie Wolfen | - | BSG Chemie Leipzig | 2:2 | ||||
| 14. Round | 12/12/1980 | BSG Stahl Thale | - | BSG Chemie Leipzig | 0:1 | ||||
| 17. Round | 13/03/1981 | BSG Chemie Leipzig | - | BSG Lokomotive Stendal | 1:1 | ||||
| 18. Round | 21/03/1981 | BSG Chemie Zeitz | - | BSG Chemie Leipzig | 1:1 | ||||
| 19. Round | 28/03/1981 | BSG Chemie Leipzig | - | BSG Stahl Blankenburg | 1:3 | ||||
| 20. Round | 03/04/1981 | BSG MK Sangerhausen | - | BSG Chemie Leipzig | 1:1 | ||||
| 21. Round | 11/04/1981 | BSG Chemie Leipzig | - | Chemie Schönebeck | 4:0 | |
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| 22. Round | 16/04/1981 | BSG Stahl Nordwest Leipzig | - | BSG Chemie Leipzig | 1:3 |
Germany