| 4. Round | 12/09/2021 | FSV Duisburg | - | VfB 03 Hilden | 0:1 | ||||
| 5. Round | 18/09/2021 | SC Velbert | - | FSV Duisburg | 2:0 | ||||
| 6. Round | 26/09/2021 | FSV Duisburg | - | Sportfreunde Niederwenigern | 3:3 | ||||
| 7. Round | 03/10/2021 | TV Jahn Hiesfeld | - | FSV Duisburg | 0:0 | ||||
| 8. Round | 10/10/2021 | FSV Duisburg | - | SpVg Schonnebeck | 1:2 | ||||
| 9. Round | 17/10/2021 | Cronenberger SC | - | FSV Duisburg | 2:1 | ||||
| 10. Round | 24/10/2021 | FSV Duisburg | - | SC Union Nettetal | 1:2 |  |
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| 11. Round | 31/10/2021 | SC Düsseldorf-West | - | FSV Duisburg | 0:1 | ||||
| 12. Round | 07/11/2021 | FSV Duisburg | - | Sportfreunde Baumberg | 0:1 | ||||
| 14. Round | 28/11/2021 | FSV Duisburg | - | TSV Meerbusch | 1:1 | |
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| 15. Round | 05/12/2021 | 1. FC Bocholt | - | FSV Duisburg | 3:0 | ||||
| 16. Round | 12/12/2021 | FSV Duisburg | - | SSVg Velbert | 0:2 | ||||
| 17. Round | 18/12/2021 | TVD Velbert | - | FSV Duisburg | 3:1 | ||||
| 18. Round | 20/02/2022 | FSV Duisburg | - | SpVgg Sterkrade-Nord | 6:1 | ||||
| 22. Round | 20/03/2022 | FSV Duisburg | - | TuRU Düsseldorf | 2:0 |
Germany
Turkey