| 1. Round | 22/08/2021 | SpVg Schonnebeck | - | Schwarz-Weiß Essen | 5:0 |  |
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| 2. Round | 29/08/2021 | FC Kray | - | SpVg Schonnebeck | 2:5 | ||||
| 3. Round | 05/09/2021 | SpVg Schonnebeck | - | DJK Teutonia St. Tönis | 3:0 | ||||
| 4. Round | 12/09/2021 | TuRU Düsseldorf | - | SpVg Schonnebeck | 3:3 | |
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| 6. Round | 26/09/2021 | 1. FC Monheim | - | SpVg Schonnebeck | 1:1 | ||||
| 7. Round | 03/10/2021 | SpVg Schonnebeck | - | 1. FC Mönchengladbach | 2:2 |  |
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| 12. Round | 07/11/2021 | TV Jahn Hiesfeld | - | SpVg Schonnebeck | 0:3 | ||||
| 14. Round | 28/11/2021 | SpVg Schonnebeck | - | Cronenberger SC | 3:1 | |
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| 16. Round | 12/12/2021 | SpVg Schonnebeck | - | SC Düsseldorf-West | 5:0 | ||||
| 17. Round | 18/12/2021 | Sportfreunde Baumberg | - | SpVg Schonnebeck | 2:2 | ||||
| 19. Round | 27/02/2022 | TSV Meerbusch | - | SpVg Schonnebeck | 0:3 | |
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| 21. Round | 11/03/2022 | SSVg Velbert | - | SpVg Schonnebeck | 1:0 | ||||
| 22. Round | 20/03/2022 | SpVg Schonnebeck | - | TVD Velbert | 3:0 |
Germany