| 1. Round | 16/08/1959 | FV Speyer | - | FK Pirmasens | 0:3 | ||||
| 2. Round | 23/08/1959 | 1. FC Saarbrücken | - | FV Speyer | 4:2 | ||||
| 3. Round | 30/08/1959 | FV Speyer | - | Sportfreunde Saarbrücken | 5:1 |  |
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| 4. Round | 06/09/1959 | 1. FC Kaiserslautern | - | FV Speyer | 4:0 | ||||
| 5. Round | 13/09/1959 | FV Speyer | - | VfR Frankenthal | 1:0 | ||||
| 6. Round | 20/09/1959 | Ludwigshafener SC | - | FV Speyer | 6:0 | ||||
| 7. Round | 27/09/1959 | FV Speyer | - | SV Phönix 03 | 0:1 | ||||
| 8. Round | 11/10/1959 | Eintracht Trier | - | FV Speyer | 1:1 | |
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| 9. Round | 18/10/1959 | VfR Kaiserslautern | - | FV Speyer | 2:2 | ||||
| 10. Round | 25/10/1959 | FV Speyer | - | Borussia Neunkirchen | 1:3 | ||||
| 12. Round | 15/11/1959 | Eintracht Bad Kreuznach | - | FV Speyer | 0:0 | ||||
| 14. Round | 29/11/1959 | FV Speyer | - | 1. FSV Mainz 05 | 1:3 | ||||
| 15. Round | 06/12/1959 | FV Speyer | - | Saar 05 Saarbrücken | 0:4 |
Germany