| 2. Round | 05/09/2021 | SC Paderborn 07 II | - | TSG Sprockhövel | 4:0 | ||||
| 3. Round | 12/09/2021 | TSG Sprockhövel | - | RSV Meinerzhagen | 6:1 | ||||
| 4. Round | 19/09/2021 | Westfalia Herne | - | TSG Sprockhövel | 1:1 | ||||
| 5. Round | 26/09/2021 | TSG Sprockhövel | - | Westfalia Rhynern | 5:0 |  |
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| 6. Round | 03/10/2021 | Holzwickeder SC | - | TSG Sprockhövel | 0:5 |  |
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| 8. Round | 17/10/2021 | SG Finnentrop/Bamenohl | - | TSG Sprockhövel | 2:1 | ||||
| 11. Round | 05/11/2021 | TSG Sprockhövel | - | TuS Ennepetal | 5:2 | |
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| 16. Round | 10/12/2021 | TSG Sprockhövel | - | Hammer SpVg | 0:1 | ||||
| 13. Round | 16/12/2021 | TSG Sprockhövel | - | SG Wattenscheid 09 | 4:1 | |
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| 14. Round | 13/02/2022 | FCE Rheine | - | TSG Sprockhövel | 2:1 | ||||
| 17. Round | 17/03/2022 | Sportfreunde Siegen | - | TSG Sprockhövel | 1:2 | ||||
| 20. Round | 20/03/2022 | TSG Sprockhövel | - | TuS Haltern | 4:1 | ||||
| 19. Round | 07/04/2022 | FC Gütersloh | - | TSG Sprockhövel | 2:0 |
Germany