| 1. Round | 15/08/2021 | Fortuna Köln II | - | SV 1914 Eilendorf | 1:2 | ||||
| 2. Round | 19/08/2021 | Viktoria Arnoldsweiler | - | Fortuna Köln II | 3:0 | ||||
| 3. Round | 22/08/2021 | Fortuna Köln II | - | Siegburger SV 04 | 1:2 | ||||
| 4. Round | 29/08/2021 | Spvg Wesseling-Urfeld | - | Fortuna Köln II | 3:1 | ||||
| 5. Round | 05/09/2021 | Fortuna Köln II | - | SV Breinig | 2:0 | ||||
| 8. Round | 26/09/2021 | VfL Alfter | - | Fortuna Köln II | 2:0 | ||||
| 9. Round | 07/10/2021 | Fortuna Köln II | - | SV Deutz 05 | 1:1 | ||||
| 10. Round | 10/10/2021 | 1. FC Düren | - | Fortuna Köln II | 4:0 | ||||
| 11. Round | 17/10/2021 | VfL 08 Vichttal | - | Fortuna Köln II | 3:0 | ||||
| 20. Round | 06/03/2022 | Siegburger SV 04 | - | Fortuna Köln II | 1:1 | ||||
| 18. Round | 10/03/2022 | SV 1914 Eilendorf | - | Fortuna Köln II | 4:0 | ||||
| 22. Round | 20/03/2022 | SV Breinig | - | Fortuna Köln II | 0:1 | ||||
| 29. Round | 08/05/2022 | FC Hennef 05 | - | Fortuna Köln II | 4:3 |
Georgia