| 1. Round | 16/08/1980 | Hamburger SV | - | MSV Duisburg | 0:0 | ||||
| 2. Round | 19/08/1980 | MSV Duisburg | - | TSV 1860 München | 1:0 | ||||
| 3. Round | 23/08/1980 | VfL Bochum | - | MSV Duisburg | 1:1 | ||||
| 4. Round | 02/09/1980 | MSV Duisburg | - | Karlsruher SC | 2:2 |  |
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| 5. Round | 06/09/1980 | MSV Duisburg | - | 1. FC Nürnberg | 2:0 |  |
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| 6. Round | 12/09/1980 | 1. FC Kaiserslautern | - | MSV Duisburg | 1:1 | ||||
| 7. Round | 20/09/1980 | MSV Duisburg | - | 1. FC Köln | 3:4 | |
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| 8. Round | 27/09/1980 | Eintracht Frankfurt | - | MSV Duisburg | 2:1 | ||||
| 14. Round | 15/11/1980 | FC Schalke 04 | - | MSV Duisburg | 2:2 | ||||
| 20. Round | 07/02/1981 | MSV Duisburg | - | VfL Bochum | 0:3 | ||||
| 23. Round | 07/03/1981 | MSV Duisburg | - | 1. FC Kaiserslautern | 1:1 | ||||
| 26. Round | 28/03/1981 | Bor. Mönchengladbach | - | MSV Duisburg | 4:1 | ||||
| 30. Round | 08/05/1981 | Fortuna Düsseldorf | - | MSV Duisburg | 0:1 | ||||
| 31. Round | 15/05/1981 | MSV Duisburg | - | FC Schalke 04 | 5:1 | |
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| 32. Round | 30/05/1981 | Arminia Bielefeld | - | MSV Duisburg | 2:1 | ||||
| 33. Round | 06/06/1981 | MSV Duisburg | - | SV Bayer 04 Leverkusen | 2:4 | ||||
| 34. Round | 13/06/1981 | VfB Stuttgart | - | MSV Duisburg | 2:0 |
Germany