| 1. Round | 13/08/2022 | 1. FSV Mainz 05 [Youth] | - | 1899 Hoffenheim [Youth] | 4:0 | ||||
| 2. Round | 21/08/2022 | FC-Astoria Walldorf [Youth] | - | 1. FSV Mainz 05 [Youth] | 0:5 |  |
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| 3. Round | 27/08/2022 | 1. FSV Mainz 05 [Youth] | - | VfB Stuttgart [Youth] | 4:3 | ||||
| 6. Round | 09/10/2022 | SSV Reutlingen [Youth] | - | 1. FSV Mainz 05 [Youth] | 0:4 | ||||
| 12. Round | 05/02/2023 | 1. FSV Mainz 05 [Youth] | - | SC Freiburg [Youth] | 3:2 | ||||
| 13. Round | 12/02/2023 | Bayern München [Youth] | - | 1. FSV Mainz 05 [Youth] | 2:0 | ||||
| 14. Round | 19/02/2023 | 1. FSV Mainz 05 [Youth] | - | TSV 1860 München [Youth] | 1:1 | |
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| 16. Round | 04/03/2023 | 1. FSV Mainz 05 [Youth] | - | Karlsruher SC [Youth] | 0:1 |  |
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| 15. Round | 08/03/2023 | SpVgg Unterhaching [Youth] | - | 1. FSV Mainz 05 [Youth] | 0:4 | |
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| 17. Round | 11/03/2023 | Eintracht Trier [Youth] | - | 1. FSV Mainz 05 [Youth] | 0:7 |
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