| 1. Round | 30/08/1980 | BSG Chemie Wolfen | - | BSG Chemie Zeitz | 1:1 |  |
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| 2. Round | 06/09/1980 | BSG Chemie Zeitz | - | BSG Stahl Blankenburg | 0:4 | ||||
| 3. Round | 13/09/1980 | BSG MK Sangerhausen | - | BSG Chemie Zeitz | 3:1 | ||||
| 4. Round | 20/09/1980 | BSG Chemie Zeitz | - | Chemie Schönebeck | 3:1 | ||||
| 12. Round | 29/11/1980 | BSG Chemie Zeitz | - | BSG Chemie Wolfen | 3:2 | ||||
| 13. Round | 06/12/1980 | BSG Stahl Blankenburg | - | BSG Chemie Zeitz | 2:1 | ||||
| 14. Round | 12/12/1980 | BSG Chemie Zeitz | - | BSG MK Sangerhausen | 3:2 | |
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| 17. Round | 14/03/1981 | ASG Vorwärts Dessau | - | BSG Chemie Zeitz | 3:2 | ||||
| 18. Round | 21/03/1981 | BSG Chemie Zeitz | - | BSG Chemie Leipzig | 1:1 | ||||
| 19. Round | 28/03/1981 | BSG Stahl Thale | - | BSG Chemie Zeitz | 2:2 | |
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| 20. Round | 03/04/1981 | BSG Chemie Zeitz | - | SG Dynamo Eisleben | 1:0 | ||||
| 21. Round | 11/04/1981 | BSG Chemie Buna Schkopau | - | BSG Chemie Zeitz | 3:0 | ||||
| 22. Round | 16/04/1981 | BSG Chemie Zeitz | - | BSG Lokomotive Stendal | 2:1 |
Germany