| 1. Round | 30/08/1980 | BSG Chemie Wolfen | - | BSG Chemie Zeitz | 1:1 | ||||
| 2. Round | 06/09/1980 | BSG Chemie Zeitz | - | BSG Stahl Blankenburg | 0:4 | ||||
| 3. Round | 13/09/1980 | BSG MK Sangerhausen | - | BSG Chemie Zeitz | 3:1 |  |
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| 4. Round | 20/09/1980 | BSG Chemie Zeitz | - | Chemie Schönebeck | 3:1 | |
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| 5. Round | 04/10/1980 | BSG Stahl Nordwest Leipzig | - | BSG Chemie Zeitz | 0:0 | ||||
| 6. Round | 07/10/1980 | BSG Chemie Zeitz | - | ASG Vorwärts Dessau | 0:0 | ||||
| 7. Round | 18/10/1980 | BSG Chemie Leipzig | - | BSG Chemie Zeitz | 1:0 | ||||
| 8. Round | 26/10/1980 | BSG Chemie Zeitz | - | BSG Stahl Thale | 1:4 | ||||
| 10. Round | 15/11/1980 | BSG Chemie Zeitz | - | BSG Chemie Buna Schkopau | 3:5 | ||||
| 11. Round | 22/11/1980 | BSG Lokomotive Stendal | - | BSG Chemie Zeitz | 1:0 | ||||
| 21. Round | 11/04/1981 | BSG Chemie Buna Schkopau | - | BSG Chemie Zeitz | 3:0 |
Germany