| 1. Round | 13/08/1977 | BFC Dynamo | - | HFC Chemie | 2:2 |  |
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| 2. Round | 20/08/1977 | HFC Chemie | - | FC Carl Zeiss Jena | 1:2 | ||||
| 3. Round | 27/08/1977 | Dynamo Dresden | - | HFC Chemie | 2:1 | ||||
| 4. Round | 03/09/1977 | HFC Chemie | - | BSG Wismut Aue | 6:0 |  |
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| 5. Round | 10/09/1977 | BSG Sachsenring Zwickau | - | HFC Chemie | 2:3 | ||||
| 6. Round | 01/10/1977 | FC Vorwärts Frankfurt/Oder | - | HFC Chemie | 0:0 | ||||
| 7. Round | 04/10/1977 | HFC Chemie | - | 1. FC Lokomotive Leipzig | 1:0 | ||||
| 8. Round | 15/10/1977 | 1. FC Union Berlin | - | HFC Chemie | 1:1 | ||||
| 9. Round | 04/11/1977 | HFC Chemie | - | Rot-Weiß Erfurt | 3:0 | |
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| 10. Round | 18/11/1977 | FC Karl-Marx-Stadt | - | HFC Chemie | 1:1 | ||||
| 11. Round | 02/12/1977 | HFC Chemie | - | BSG Wismut Gera | 4:2 | ||||
| 12. Round | 09/12/1977 | 1. FC Magdeburg | - | HFC Chemie | 2:0 | ||||
| 13. Round | 16/12/1977 | HFC Chemie | - | BSG Chemie Böhlen | 4:0 | ||||
| 18. Round | 01/04/1978 | HFC Chemie | - | BSG Sachsenring Zwickau | 2:0 | ||||
| 19. Round | 08/04/1978 | HFC Chemie | - | FC Vorwärts Frankfurt/Oder | 2:2 | |
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| 20. Round | 14/04/1978 | 1. FC Lokomotive Leipzig | - | HFC Chemie | 2:0 |
Germany