| 5. Round | 09/10/2021 | FC Hennef 05 [Youth B] | - | Wuppertaler SV [Youth B] | 2:0 | ||||
| 6. Round | 31/10/2021 | Wuppertaler SV [Youth B] | - | FC Schalke 04 [Youth B] | 1:7 | ||||
| 7. Round | 06/11/2021 | SC Paderborn 07 [Youth B] | - | Wuppertaler SV [Youth B] | 2:0 | ||||
| 8. Round | 12/02/2022 | Wuppertaler SV [Youth B] | - | Rot-Weiss Essen [Youth B] | 0:1 | ||||
| 11. Round | 19/02/2022 | Wuppertaler SV [Youth B] | - | SG Unterrath 12/24 [Youth B] | 1:1 | ||||
| 9. Round | 23/02/2022 | 1. FC Köln [Youth B] | - | Wuppertaler SV [Youth B] | 3:1 | ||||
| 12. Round | 27/02/2022 | Bor. Mönchengladbach [Youth B] | - | Wuppertaler SV [Youth B] | 7:0 | ||||
| 13. Round | 06/03/2022 | Wuppertaler SV [Youth B] | - | Borussia Dortmund [Youth B] | 0:0 |
Germany