| 1. Round | 15/08/2021 | Heeslinger SC | - | Kickers Emden | 1:2 | ||||
| 18. Round | 18/08/2021 | Kickers Emden | - | Rotenburger SV | 2:1 |  |
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| 2. Round | 21/08/2021 | Kickers Emden | - | FC Hagen/Uthlede | 3:0 | ||||
| 3. Round | 28/08/2021 | Kickers Emden | - | SC Spelle-Venhaus | 1:1 | ||||
| 5. Round | 12/09/2021 | MTV Eintracht Celle | - | Kickers Emden | 1:2 | ||||
| 6. Round | 18/09/2021 | Kickers Emden | - | TB Uphusen | 5:1 | ||||
| 7. Round | 26/09/2021 | TuS Bersenbrück | - | Kickers Emden | 2:1 | ||||
| 8. Round | 02/10/2021 | Kickers Emden | - | VfL Oldenburg | 5:2 | ||||
| 9. Round | 10/10/2021 | Rotenburger SV | - | Kickers Emden | 1:2 | ||||
| 11. Round | 24/10/2021 | FC Hagen/Uthlede | - | Kickers Emden | 1:1 | ||||
| 12. Round | 31/10/2021 | SC Spelle-Venhaus | - | Kickers Emden | 2:1 | ||||
| 13. Round | 07/11/2021 | Blau-Weiß Lohne | - | Kickers Emden | 1:0 | ||||
| 14. Round | 13/11/2021 | Kickers Emden | - | MTV Eintracht Celle | 3:0 | ||||
| 10. Round | 17/11/2021 | Kickers Emden | - | Heeslinger SC | 1:0 |  |
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| 15. Round | 20/11/2021 | TB Uphusen | - | Kickers Emden | 1:3 | ||||
| 17. Round | 05/12/2021 | VfL Oldenburg | - | Kickers Emden | 4:1 | ||||
| 16. Round | 11/12/2021 | Kickers Emden | - | TuS Bersenbrück | 2:0 | |
Germany