| 1. Round | 14/08/1965 | Tasmania 1900 Berlin | - | Karlsruher SC | 2:0 | ||||
| 2. Round | 21/08/1965 | FC Schalke 04 | - | Karlsruher SC | 0:0 | ||||
| 3. Round | 28/08/1965 | Karlsruher SC | - | Bor. Mönchengladbach | 3:3 | ||||
| 4. Round | 04/09/1965 | Borussia Dortmund | - | Karlsruher SC | 4:1 | ||||
| 5. Round | 11/09/1965 | Karlsruher SC | - | Hamburger SV | 1:4 | ||||
| 7. Round | 02/10/1965 | Karlsruher SC | - | 1. FC Nürnberg | 1:2 | ||||
| 8. Round | 16/10/1965 | Hannover 96 | - | Karlsruher SC | 5:2 | ||||
| 9. Round | 20/10/1965 | Karlsruher SC | - | 1. FC Kaiserslautern | 1:0 | ||||
| 10. Round | 23/10/1965 | VfB Stuttgart | - | Karlsruher SC | 1:0 | ||||
| 11. Round | 30/10/1965 | Karlsruher SC | - | Meidericher SV | 0:4 | ||||
| 12. Round | 06/11/1965 | 1. FC Köln | - | Karlsruher SC | 2:0 | ||||
| 20. Round | 29/01/1966 | Bor. Mönchengladbach | - | Karlsruher SC | 1:1 | ||||
| 21. Round | 05/02/1966 | Karlsruher SC | - | Borussia Dortmund | 0:0 | ||||
| 22. Round | 12/02/1966 | Hamburger SV | - | Karlsruher SC | 8:0 | ||||
| 27. Round | 26/03/1966 | Karlsruher SC | - | VfB Stuttgart | 3:0 | ||||
| 28. Round | 02/04/1966 | Meidericher SV | - | Karlsruher SC | 8:2 | ||||
| 33. Round | 21/05/1966 | Karlsruher SC | - | Eintracht Braunschweig | 1:4 |
Germany