| 1. Round | 28/08/2021 | SpVgg Vreden | - | FC Gütersloh | 0:2 | ||||
| 2. Round | 05/09/2021 | TuS Haltern | - | SpVgg Vreden | 1:1 | ||||
| 3. Round | 12/09/2021 | SpVgg Vreden | - | TuS Erndtebrück | 1:1 |  |
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| 4. Round | 19/09/2021 | Preußen Münster II | - | SpVgg Vreden | 4:2 | ||||
| 13. Round | 20/11/2021 | SpVgg Vreden | - | Viktoria Clarholz | 2:0 | ||||
| 14. Round | 28/11/2021 | TuS Ennepetal | - | SpVgg Vreden | 0:2 | ||||
| 19. Round | 13/03/2022 | SpVgg Vreden | - | Hammer SpVg | 1:0 | ||||
| 18. Round | 30/03/2022 | TSG Sprockhövel | - | SpVgg Vreden | 2:3 | ||||
| 20. Round | 14/04/2022 | Sportfreunde Siegen | - | SpVgg Vreden | 5:2 |
Germany