| 3. Round | 15/08/1980 | OSV Hannover | - | SpVgg Erkenschwick | 4:1 | ||||
| 4. Round | 19/08/1980 | SG Union Solingen | - | OSV Hannover | 1:0 | ||||
| 5. Round | 22/08/1980 | OSV Hannover | - | Preußen Münster | 1:0 | ||||
| 6. Round | 26/08/1980 | Hertha BSC | - | OSV Hannover | 3:2 | ||||
| 7. Round | 05/09/1980 | OSV Hannover | - | Rot-Weiss Essen | 2:6 |  |
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| 17. Round | 07/11/1980 | OSV Hannover | - | VfB Oldenburg | 2:1 | ||||
| 18. Round | 14/11/1980 | SC Viktoria 04 Köln | - | OSV Hannover | 2:0 | ||||
| 19. Round | 28/11/1980 | OSV Hannover | - | Fortuna Köln | 1:0 | ||||
| 20. Round | 05/12/1980 | Alemannia Aachen | - | OSV Hannover | 2:0 |  |
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| 21. Round | 12/12/1980 | OSV Hannover | - | Eintracht Braunschweig | 0:3 | ||||
| 23. Round | 09/01/1981 | OSV Hannover | - | Holstein Kiel | 0:1 |
Germany