| 1. Round | 13/08/2021 | SSV Ulm 1846 | - | FSV Frankfurt | 3:3 | ||||
| 2. Round | 20/08/2021 | FSV Frankfurt | - | Rot-Weiß Koblenz | 0:1 |  |
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| 4. Round | 28/08/2021 | FSV Frankfurt | - | Hessen Kassel | 1:0 | ||||
| 5. Round | 03/09/2021 | FC-Astoria Walldorf | - | FSV Frankfurt | 2:1 | ||||
| 6. Round | 10/09/2021 | FSV Frankfurt | - | 1. FSV Mainz 05 II | 1:2 | ||||
| 7. Round | 14/09/2021 | TSV Schott Mainz | - | FSV Frankfurt | 0:1 |  |
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| 8. Round | 18/09/2021 | FSV Frankfurt | - | FK Pirmasens | 2:2 | ||||
| 18. Round | 13/11/2021 | SV 07 Elversberg | - | FSV Frankfurt | 4:2 | ||||
| 19. Round | 21/11/2021 | FSV Frankfurt | - | Kickers Offenbach | 0:2 |
Germany