| 1. Round | 15/08/2021 | SG 99 Andernach [Women] | - | Borussia Bocholt [Women] | 3:1 |  |
|||
| 2. Round | 29/08/2021 | Borussia Bocholt [Women] | - | FSV Gütersloh 2009 [Women] | 1:2 | |
|||
| 3. Round | 05/09/2021 | Borussia Bocholt [Women] | - | SV 07 Elversberg [Women] | 2:2 | ||||
| 5. Round | 03/10/2021 | Borussia Bocholt [Women] | - | 1. FC Nürnberg [Women] | 0:4 | |
|||
| 7. Round | 17/10/2021 | Borussia Bocholt [Women] | - | RB Leipzig [Women] | 1:9 | ||||
| 8. Round | 07/11/2021 | MSV Duisburg [Women] | - | Borussia Bocholt [Women] | 3:0 | ||||
| 9. Round | 13/11/2021 | Borussia Bocholt [Women] | - | VfL Wolfsburg II [Women] | 1:1 | ||||
| 10. Round | 21/11/2021 | 1899 Hoffenheim II [Women] | - | Borussia Bocholt [Women] | 0:2 | ||||
| 11. Round | 05/12/2021 | Borussia Bocholt [Women] | - | Bayern München II [Women] | 0:3 | ||||
| 12. Round | 12/12/2021 | Eintracht Frankfurt II [Women] | - | Borussia Bocholt [Women] | 3:2 | ||||
| 13. Round | 19/12/2021 | Borussia Bocholt [Women] | - | SV Meppen [Women] | 1:3 |
Germany