| 1. Round | 27/08/2021 | 1899 Hoffenheim [Women] | - | SC Freiburg [Women] | 2:1 | ||||
| 13. Round | 04/02/2022 | 1899 Hoffenheim [Women] | - | 1. FC Köln [Women] | 1:1 | ||||
| 14. Round | 13/02/2022 | 1899 Hoffenheim [Women] | - | SGS Essen [Women] | 2:1 | ||||
| 15. Round | 05/03/2022 | Eintracht Frankfurt [Women] | - | 1899 Hoffenheim [Women] | 3:2 | ||||
| 16. Round | 12/03/2022 | 1899 Hoffenheim [Women] | - | Bayern München [Women] | 2:4 | ||||
| 17. Round | 19/03/2022 | VfL Wolfsburg [Women] | - | 1899 Hoffenheim [Women] | 3:0 | ||||
| 18. Round | 27/03/2022 | 1899 Hoffenheim [Women] | - | FC Carl Zeiss Jena [Women] | 6:0 | ||||
| 20. Round | 23/04/2022 | 1899 Hoffenheim [Women] | - | Turbine Potsdam [Women] | 1:2 | ||||
| 21. Round | 08/05/2022 | Werder Bremen [Women] | - | 1899 Hoffenheim [Women] | 0:1 | ||||
| 22. Round | 15/05/2022 | 1899 Hoffenheim [Women] | - | SC Sand [Women] | 3:3 |
Germany
Austria