| 1. Round | 22/08/2021 | FSV Duisburg | - | 1. FC Monheim | 2:0 | ||||
| 6. Round | 26/09/2021 | FSV Duisburg | - | Sportfreunde Niederwenigern | 3:3 |  |
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| 7. Round | 03/10/2021 | TV Jahn Hiesfeld | - | FSV Duisburg | 0:0 | ||||
| 8. Round | 10/10/2021 | FSV Duisburg | - | SpVg Schonnebeck | 1:2 | ||||
| 9. Round | 17/10/2021 | Cronenberger SC | - | FSV Duisburg | 2:1 | ||||
| 12. Round | 07/11/2021 | FSV Duisburg | - | Sportfreunde Baumberg | 0:1 |
Germany