| 3. Round | 11/09/2021 | 1. FSV Mainz 05 [Youth] | - | FC Ingolstadt 04 [Youth] | 4:3 | ||||
| 8. Round | 24/10/2021 | 1. FC Heidenheim 1846 [Youth] | - | 1. FSV Mainz 05 [Youth] | 0:3 | ||||
| 11. Round | 28/11/2021 | 1. FSV Mainz 05 [Youth] | - | SSV Ulm 1846 [Youth] | 3:2 | ||||
| 12. Round | 04/12/2021 | Bayern München [Youth] | - | 1. FSV Mainz 05 [Youth] | 7:2 | ||||
| 19. Round | 09/04/2022 | 1. FSV Mainz 05 [Youth] | - | 1. FC Nürnberg [Youth] | 3:5 |
Croatia