| 1. Round | 07/08/2010 | 1899 Hoffenheim II | - | FSV Frankfurt II | 4:0 | ||||
| 3. Round | 22/08/2010 | 1899 Hoffenheim II | - | FC Memmingen | 6:0 | ||||
| 5. Round | 31/08/2010 | 1899 Hoffenheim II | - | SG Sonnenhof Großaspach | 0:1 | ||||
| 7. Round | 11/09/2010 | 1899 Hoffenheim II | - | Stuttgarter Kickers | 1:1 | ||||
| 8. Round | 18/09/2010 | 1. FC Nürnberg II | - | 1899 Hoffenheim II | 1:2 | ||||
| 9. Round | 22/09/2010 | SpVgg Weiden | - | 1899 Hoffenheim II | annull. | ||||
| 16. Round | 13/11/2010 | 1899 Hoffenheim II | - | SpVgg Greuther Fürth II | 2:3 | ||||
| 18. Round | 28/11/2010 | 1899 Hoffenheim II | - | Wormatia Worms | 1:2 | ||||
| 21. Round | 20/04/2011 | FC Memmingen | - | 1899 Hoffenheim II | 0:3 | ||||
| 29. Round | 25/04/2011 | SSV Ulm 1846 | - | 1899 Hoffenheim II | annull. | ||||
| 30. Round | 29/04/2011 | 1899 Hoffenheim II | - | SC Freiburg II | 1:1 |  |
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| 31. Round | 07/05/2011 | Hessen Kassel | - | 1899 Hoffenheim II | 3:4 | ||||
| 32. Round | 13/05/2011 | 1899 Hoffenheim II | - | Karlsruher SC II | 1:5 | ||||
| 33. Round | 21/05/2011 | SpVgg Greuther Fürth II | - | 1899 Hoffenheim II | 1:1 | ||||
| 34. Round | 28/05/2011 | 1899 Hoffenheim II | - | Eintracht Frankfurt II | 1:2 |
Germany