| 1. Round | 06/08/2022 | Bor. Mönchengladbach | - | 1899 Hoffenheim | 3:1 | ||||
| 2. Round | 13/08/2022 | 1899 Hoffenheim | - | VfL Bochum | 3:2 | ||||
| 3. Round | 20/08/2022 | Bayer Leverkusen | - | 1899 Hoffenheim | 0:3 | ||||
| 4. Round | 27/08/2022 | 1899 Hoffenheim | - | FC Augsburg | 1:0 | ||||
| 5. Round | 02/09/2022 | Borussia Dortmund | - | 1899 Hoffenheim | 1:0 | ||||
| 8. Round | 02/10/2022 | Hertha BSC | - | 1899 Hoffenheim | 1:1 | ||||
| 9. Round | 07/10/2022 | 1899 Hoffenheim | - | Werder Bremen | 1:2 | ||||
| 10. Round | 14/10/2022 | FC Schalke 04 | - | 1899 Hoffenheim | 0:3 | ||||
| 12. Round | 30/10/2022 | 1. FC Köln | - | 1899 Hoffenheim | 1:1 |  |
|||
| 13. Round | 05/11/2022 | 1899 Hoffenheim | - | RB Leipzig | 1:3 | ||||
| 15. Round | 12/11/2022 | 1899 Hoffenheim | - | VfL Wolfsburg | 1:2 | ||||
| 34. Round | 27/05/2023 | VfB Stuttgart | - | 1899 Hoffenheim | 1:1 |
Denmark
