| 5. Round | 03/10/2021 | FSV Gütersloh 2009 [Women] | - | 1899 Hoffenheim II [Women] | 1:1 | ||||
| 9. Round | 14/11/2021 | FSV Gütersloh 2009 [Women] | - | Eintracht Frankfurt II [Women] | 0:1 | ||||
| 10. Round | 21/11/2021 | SV Henstedt-Ulzburg [Women] | - | FSV Gütersloh 2009 [Women] | 2:5 |  |
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| 12. Round | 12/12/2021 | FSV Gütersloh 2009 [Women] | - | RB Leipzig [Women] | 1:4 | ||||
| 13. Round | 19/12/2021 | SG 99 Andernach [Women] | - | FSV Gütersloh 2009 [Women] | 3:3 | ||||
| 15. Round | 06/03/2022 | FSV Gütersloh 2009 [Women] | - | Borussia Bocholt [Women] | 3:1 | ||||
| 16. Round | 13/03/2022 | VfL Wolfsburg II [Women] | - | FSV Gütersloh 2009 [Women] | 1:3 | ||||
| 17. Round | 20/03/2022 | FSV Gütersloh 2009 [Women] | - | SV 07 Elversberg [Women] | 0:0 | ||||
| 18. Round | 27/03/2022 | 1899 Hoffenheim II [Women] | - | FSV Gütersloh 2009 [Women] | 0:0 | ||||
| 19. Round | 03/04/2022 | FSV Gütersloh 2009 [Women] | - | FC Ingolstadt 04 [Women] | 0:4 | ||||
| 23. Round | 08/05/2022 | FSV Gütersloh 2009 [Women] | - | SV Henstedt-Ulzburg [Women] | 4:1 | ||||
| 24. Round | 15/05/2022 | SV Meppen [Women] | - | FSV Gütersloh 2009 [Women] | 2:2 |
Germany