| 23. Round | 29/01/2022 | FC Schalke 04 II | - | Sportfreunde Lotte | 4:1 | ||||
| 19. Round | 15/02/2022 | Sportfreunde Lotte | - | Fortuna Köln | 1:2 | ||||
| 27. Round | 26/02/2022 | SC Wiedenbrück | - | Sportfreunde Lotte | 1:1 | ||||
| 22. Round | 02/03/2022 | Sportfreunde Lotte | - | Preußen Münster | 2:3 | ||||
| 28. Round | 05/03/2022 | Sportfreunde Lotte | - | 1. FC Köln II | 1:1 | ||||
| 29. Round | 12/03/2022 | Alemannia Aachen | - | Sportfreunde Lotte | 1:0 | ||||
| 24. Round | 16/03/2022 | Sportfreunde Lotte | - | SV Lippstadt 08 | 0:2 | ||||
| 30. Round | 19/03/2022 | Sportfreunde Lotte | - | Bor. Mönchengladbach II | 2:0 | ||||
| 25. Round | 30/03/2022 | Rot-Weiß Oberhausen | - | Sportfreunde Lotte | 1:0 | ||||
| 34. Round | 16/04/2022 | Rot Weiss Ahlen | - | Sportfreunde Lotte | 1:1 | ||||
| 38. Round | 14/05/2022 | Fortuna Köln | - | Sportfreunde Lotte | 2:1 |
Poland
Germany