| 4. Round | 19/09/2021 | Empoli FC | - | Sampdoria | 0:3 | ||||
| 9. Round | 22/10/2021 | Sampdoria | - | Spezia Calcio | 2:1 | ||||
| 10. Round | 27/10/2021 | Sampdoria | - | Atalanta | 1:3 |  |
|||
| 11. Round | 30/10/2021 | Torino FC | - | Sampdoria | 3:0 | |
|||
| 12. Round | 07/11/2021 | Sampdoria | - | Bologna FC | 1:2 | ||||
| 13. Round | 21/11/2021 | US Salernitana 1919 | - | Sampdoria | 0:2 | |
|||
| 15. Round | 30/11/2021 | ACF Fiorentina | - | Sampdoria | 3:1 | ||||
| 16. Round | 05/12/2021 | Sampdoria | - | Lazio Roma | 1:3 | ||||
| 17. Round | 10/12/2021 | Genoa CFC | - | Sampdoria | 1:3 | |
|||
| 20. Round | 06/01/2022 | Sampdoria | - | Cagliari Calcio | 1:2 | ||||
| 21. Round | 09/01/2022 | SSC Napoli | - | Sampdoria | 1:0 | |
Germany
France