| 2. Round | 18/09/2021 | Fortuna Düsseldorf [Youth B] | - | Arminia Bielefeld [Youth B] | 5:0 |  |
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| 4. Round | 03/10/2021 | Fortuna Düsseldorf [Youth B] | - | SV Lippstadt 08 [Youth B] | 4:1 |  |
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| 5. Round | 10/10/2021 | VfL Bochum [Youth B] | - | Fortuna Düsseldorf [Youth B] | 2:3 | ||||
| 7. Round | 06/11/2021 | Alemannia Aachen [Youth B] | - | Fortuna Düsseldorf [Youth B] | 1:4 | ||||
| 8. Round | 28/11/2021 | Fortuna Düsseldorf [Youth B] | - | Fortuna Köln [Youth B] | 4:2 | ||||
| 10. Round | 11/12/2021 | Fortuna Düsseldorf [Youth B] | - | FC Schalke 04 [Youth B] | 0:0 | ||||
| 11. Round | 20/02/2022 | SC Paderborn 07 [Youth B] | - | Fortuna Düsseldorf [Youth B] | 1:3 | ||||
| 12. Round | 26/02/2022 | Fortuna Düsseldorf [Youth B] | - | Rot-Weiss Essen [Youth B] | 4:0 | ||||
| 13. Round | 05/03/2022 | 1. FC Köln [Youth B] | - | Fortuna Düsseldorf [Youth B] | 5:1 | ||||
| 14. Round | 13/03/2022 | Fortuna Düsseldorf [Youth B] | - | Wuppertaler SV [Youth B] | 2:0 | ||||
| 17. Round | 23/04/2022 | Borussia Dortmund [Youth B] | - | Fortuna Düsseldorf [Youth B] | 2:3 |
Ghana