| 2. Round | 29/08/2021 | RB Leipzig [Women] | - | 1899 Hoffenheim II [Women] | 2:0 |  |
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| 17. Round | 20/03/2022 | Eintracht Frankfurt II [Women] | - | RB Leipzig [Women] | 2:2 | ||||
| 18. Round | 27/03/2022 | RB Leipzig [Women] | - | SV Meppen [Women] | 4:2 | ||||
| 19. Round | 20/04/2022 | SG 99 Andernach [Women] | - | RB Leipzig [Women] | 5:0 | ||||
| 21. Round | 24/04/2022 | SV 07 Elversberg [Women] | - | RB Leipzig [Women] | 0:3 | ||||
| 22. Round | 01/05/2022 | RB Leipzig [Women] | - | FC Ingolstadt 04 [Women] | 4:3 | ||||
| 23. Round | 08/05/2022 | RB Leipzig [Women] | - | 1. FC Nürnberg [Women] | 2:1 |  |
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| 24. Round | 15/05/2022 | RB Leipzig [Women] | - | SV Henstedt-Ulzburg [Women] | 3:1 | ||||
| 25. Round | 22/05/2022 | RB Leipzig [Women] | - | FSV Gütersloh 2009 [Women] | 6:1 | ||||
| 26. Round | 05/06/2022 | MSV Duisburg [Women] | - | RB Leipzig [Women] | 6:1 |
Germany