| 14. Round | 28/10/2000 | Karlsruher SC | - | 1. FC Schweinfurt 05 | 4:1 |  |
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| 15. Round | 04/11/2000 | VfR Aalen | - | Karlsruher SC | 0:3 | ||||
| 16. Round | 11/11/2000 | Karlsruher SC | - | SV Wehen-Taunusstein | 4:0 | ||||
| 17. Round | 18/11/2000 | FC Carl Zeiss Jena | - | Karlsruher SC | 0:1 | ||||
| 18. Round | 25/11/2000 | Sportfreunde Siegen | - | Karlsruher SC | 1:1 | ||||
| 19. Round | 02/12/2000 | Karlsruher SC | - | TSV 1860 München II | 1:1 | ||||
| 20. Round | 09/12/2000 | Karlsruher SC | - | SC Pfullendorf | 2:1 |  |
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| 22. Round | 03/03/2001 | Karlsruher SC | - | SV Darmstadt 98 | 0:0 |  |
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| 23. Round | 10/03/2001 | Wacker Burghausen | - | Karlsruher SC | 1:0 |
Germany