| 1. Round | 14/08/2021 | FC Carl Zeiss Jena [Youth B] | - | FC Viktoria 1889 Berlin [Youth B] | 0:2 | ||||
| 2. Round | 21/08/2021 | Erzgebirge Aue [Youth B] | - | FC Carl Zeiss Jena [Youth B] | 1:0 | ||||
| 3. Round | 28/08/2021 | FC Carl Zeiss Jena [Youth B] | - | RB Leipzig [Youth B] | 0:3 | ||||
| 4. Round | 11/09/2021 | FC St. Pauli [Youth B] | - | FC Carl Zeiss Jena [Youth B] | 4:0 | ||||
| 6. Round | 25/09/2021 | Hertha BSC [Youth B] | - | FC Carl Zeiss Jena [Youth B] | 2:0 | ||||
| 7. Round | 02/10/2021 | FC Carl Zeiss Jena [Youth B] | - | VfL Wolfsburg [Youth B] | 1:1 | ||||
| 8. Round | 09/10/2021 | Eintracht Braunschweig [Youth B] | - | FC Carl Zeiss Jena [Youth B] | 1:0 | ||||
| 9. Round | 30/10/2021 | FC Carl Zeiss Jena [Youth B] | - | Werder Bremen [Youth B] | 1:2 | ||||
| 11. Round | 12/02/2022 | FC Carl Zeiss Jena [Youth B] | - | Hamburger SV [Youth B] | 0:3 |  |
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| 16. Round | 12/03/2022 | FC Carl Zeiss Jena [Youth B] | - | Hallescher FC [Youth B] | 3:0 | ||||
| 17. Round | 03/04/2022 | 1. FC Union Berlin [Youth B] | - | FC Carl Zeiss Jena [Youth B] | 0:1 | ||||
| 19. Round | 23/04/2022 | Dynamo Dresden [Youth B] | - | FC Carl Zeiss Jena [Youth B] | 0:3 |
Germany