| 1. Round | 04/08/1980 | 1. FC Saarbrücken | - | VfR Bürstadt | 0:2 | ||||
| 2. Round | 08/08/1980 | Stuttgarter Kickers | - | 1. FC Saarbrücken | 1:0 | ||||
| 3. Round | 14/08/1980 | 1. FC Saarbrücken | - | ESV Ingolstadt | 5:1 | ||||
| 4. Round | 18/08/1980 | Kickers Offenbach | - | 1. FC Saarbrücken | 5:1 | ||||
| 5. Round | 22/08/1980 | 1. FC Saarbrücken | - | Freiburger FC | 2:2 | ||||
| 6. Round | 28/08/1980 | SSV Ulm 1846 | - | 1. FC Saarbrücken | 3:2 | ||||
| 7. Round | 04/09/1980 | 1. FC Saarbrücken | - | SpVgg Bayreuth | 0:2 | ||||
| 8. Round | 11/09/1980 | SpVgg Fürth | - | 1. FC Saarbrücken | 2:0 |  |
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| 9. Round | 19/09/1980 | Waldhof Mannheim | - | 1. FC Saarbrücken | 2:1 | ||||
| 10. Round | 25/09/1980 | 1. FC Saarbrücken | - | FC 08 Homburg | 2:3 | ||||
| 11. Round | 10/10/1980 | Wormatia Worms | - | 1. FC Saarbrücken | 1:0 | ||||
| 12. Round | 17/10/1980 | 1. FC Saarbrücken | - | FSV Frankfurt | 3:1 | ||||
| 17. Round | 27/11/1980 | VfB Eppingen | - | 1. FC Saarbrücken | 4:0 | ||||
| 18. Round | 27/12/1980 | 1. FC Saarbrücken | - | Eintracht Trier | 1:1 | ||||
| 22. Round | 27/02/1981 | ESV Ingolstadt | - | 1. FC Saarbrücken | 3:1 | ||||
| 36. Round | 07/05/1981 | 1. FC Saarbrücken | - | VfB Eppingen | 1:0 |
Germany