| 21. Round | 27/07/2018 | FC Eddersheim | - | SpVgg Neu-Isenburg | 2:1 | ||||
| 4. Round | 19/08/2018 | FC Ederbergland | - | SpVgg Neu-Isenburg | 1:4 | ||||
| 5. Round | 26/08/2018 | SpVgg Neu-Isenburg | - | FC Eddersheim | 1:3 | ||||
| 6. Round | 01/09/2018 | Hünfelder SV | - | SpVgg Neu-Isenburg | 0:2 |  |
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| 8. Round | 09/09/2018 | SpVgg Neu-Isenburg | - | FSC Lohfelden | 4:1 | ||||
| 9. Round | 15/09/2018 | FC Gießen | - | SpVgg Neu-Isenburg | 4:1 | ||||
| 11. Round | 29/09/2018 | Bayern Alzenau | - | SpVgg Neu-Isenburg | 5:1 | ||||
| 12. Round | 03/10/2018 | SpVgg Neu-Isenburg | - | VfB Ginsheim | 5:3 | ||||
| 13. Round | 06/10/2018 | FV Bad Vilbel | - | SpVgg Neu-Isenburg | 1:1 | ||||
| 14. Round | 14/10/2018 | SpVgg Neu-Isenburg | - | Viktoria Griesheim | 1:2 | ||||
| 15. Round | 20/10/2018 | SV Rot-Weiss Hadamar | - | SpVgg Neu-Isenburg | 9:0 |
Germany