| 1. Round | 24/07/2021 | 1. FC Heidenheim 1846 | - | SC Paderborn 07 | 0:0 | ||||
| 2. Round | 30/07/2021 | SC Paderborn 07 | - | 1. FC Nürnberg | 2:2 | ||||
| 7. Round | 19/09/2021 | Erzgebirge Aue | - | SC Paderborn 07 | 1:4 | ||||
| 9. Round | 02/10/2021 | Fortuna Düsseldorf | - | SC Paderborn 07 | 2:3 | ||||
| 16. Round | 04/12/2021 | SV Sandhausen | - | SC Paderborn 07 | 1:1 | ||||
| 25. Round | 04/03/2022 | Holstein Kiel | - | SC Paderborn 07 | 3:4 |
Germany