| 2. Round | 19/09/2021 | Borussia Dortmund [Youth] | - | SC Paderborn 07 [Youth] | 3:1 | ||||
| 3. Round | 25/09/2021 | Fortuna Köln [Youth] | - | Borussia Dortmund [Youth] | 1:4 | ||||
| 6. Round | 24/10/2021 | Borussia Dortmund [Youth] | - | FC Schalke 04 [Youth] | 4:0 | ||||
| 7. Round | 30/10/2021 | 1. FC Köln [Youth] | - | Borussia Dortmund [Youth] | 0:1 |  |
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| 9. Round | 25/02/2022 | Borussia Dortmund [Youth] | - | Alemannia Aachen [Youth] | 5:0 | ||||
| 13. Round | 05/03/2022 | Borussia Dortmund [Youth] | - | Viktoria Köln [Youth] | 0:0 | ||||
| 16. Round | 23/04/2022 | Preußen Münster [Youth] | - | Borussia Dortmund [Youth] | 1:5 | ||||
| 17. Round | 30/04/2022 | Borussia Dortmund [Youth] | - | Rot-Weiss Essen [Youth] | 1:0 | |
Germany