| 9. Round | 02/10/2021 | Fortuna Düsseldorf | - | SC Paderborn 07 | 2:3 | ||||
| 13. Round | 06/11/2021 | SC Paderborn 07 | - | FC Ingolstadt 04 | 2:1 | ||||
| 14. Round | 19/11/2021 | Hannover 96 | - | SC Paderborn 07 | 0:0 | ||||
| 15. Round | 28/11/2021 | SC Paderborn 07 | - | Hansa Rostock | 1:1 | ||||
| 16. Round | 04/12/2021 | SV Sandhausen | - | SC Paderborn 07 | 1:1 |  |
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| 17. Round | 11/12/2021 | SC Paderborn 07 | - | SV Darmstadt 98 | 0:1 | ||||
| 18. Round | 18/12/2021 | SC Paderborn 07 | - | 1. FC Heidenheim 1846 | 1:2 |  |
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| 19. Round | 15/01/2022 | 1. FC Nürnberg | - | SC Paderborn 07 | 1:2 | ||||
| 20. Round | 22/01/2022 | SC Paderborn 07 | - | Werder Bremen | 3:4 | ||||
| 22. Round | 12/02/2022 | SC Paderborn 07 | - | Dynamo Dresden | 0:0 | ||||
| 23. Round | 18/02/2022 | FC Schalke 04 | - | SC Paderborn 07 | 2:0 | ||||
| 26. Round | 12/03/2022 | SC Paderborn 07 | - | Fortuna Düsseldorf | 1:1 | ||||
| 27. Round | 20/03/2022 | Jahn Regensburg | - | SC Paderborn 07 | 1:0 | ||||
| 30. Round | 17/04/2022 | FC Ingolstadt 04 | - | SC Paderborn 07 | 0:1 | ||||
| 31. Round | 24/04/2022 | SC Paderborn 07 | - | Hannover 96 | 3:0 | ||||
| 34. Round | 15/05/2022 | SV Darmstadt 98 | - | SC Paderborn 07 | 3:0 |
Germany