| 1. Round | 11/09/2021 | FC Hennef 05 [Youth B] | - | FC Schalke 04 [Youth B] | 1:2 |  |
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| 2. Round | 19/09/2021 | SC Paderborn 07 [Youth B] | - | FC Hennef 05 [Youth B] | 3:0 | ||||
| 3. Round | 25/09/2021 | FC Hennef 05 [Youth B] | - | Rot-Weiss Essen [Youth B] | 0:1 | ||||
| 5. Round | 09/10/2021 | FC Hennef 05 [Youth B] | - | Wuppertaler SV [Youth B] | 2:0 | |
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| 6. Round | 31/10/2021 | SG Unterrath 12/24 [Youth B] | - | FC Hennef 05 [Youth B] | 0:1 | ||||
| 7. Round | 14/11/2021 | FC Hennef 05 [Youth B] | - | Bor. Mönchengladbach [Youth B] | 2:4 | ||||
| 14. Round | 12/03/2022 | Preußen Münster [Youth B] | - | FC Hennef 05 [Youth B] | 4:1 |
Germany