| 1. Round | 06/08/2011 | Rot-Weiss Essen | - | 1. FSV Mainz 05 II | 2:1 | ||||
| 11. Round | 15/10/2011 | Borussia Dortmund II | - | 1. FSV Mainz 05 II | 2:3 | ||||
| 15. Round | 19/11/2011 | 1. FSV Mainz 05 II | - | 1. FC Köln II | 3:1 | ||||
| 18. Round | 10/12/2011 | SC Verl | - | 1. FSV Mainz 05 II | 1:0 | ||||
| 19. Round | 14/12/2011 | 1. FSV Mainz 05 II | - | Bor. Mönchengladbach II | 1:2 | ||||
| 20. Round | 21/01/2012 | 1. FSV Mainz 05 II | - | Rot-Weiss Essen | 1:2 | ||||
| 21. Round | 28/01/2012 | VfL Bochum II | - | 1. FSV Mainz 05 II | 2:2 | ||||
| 22. Round | 04/02/2012 | 1. FSV Mainz 05 II | - | Wuppertaler SV | 1:2 | ||||
| 24. Round | 17/02/2012 | 1. FSV Mainz 05 II | - | Bayer Leverkusen II | 1:2 | ||||
| 25. Round | 24/02/2012 | Sportfreunde Lotte | - | 1. FSV Mainz 05 II | 1:0 | ||||
| 31. Round | 05/04/2012 | Fortuna Düsseldorf II | - | 1. FSV Mainz 05 II | 1:2 | ||||
| 32. Round | 11/04/2012 | 1. FSV Mainz 05 II | - | Fortuna Köln | 3:1 | ||||
| 35. Round | 28/04/2012 | 1. FSV Mainz 05 II | - | SV 07 Elversberg | 5:0 | ||||
| 38. Round | 19/05/2012 | Bor. Mönchengladbach II | - | 1. FSV Mainz 05 II | 3:0 |  |
Germany