| 2. Round | 17/08/2010 | Eintracht Frankfurt II | - | SV Wehen Wiesbaden II | 1:2 | ||||
| 4. Round | 28/08/2010 | Wormatia Worms | - | SV Wehen Wiesbaden II | 2:0 | ||||
| 5. Round | 31/08/2010 | SV Wehen Wiesbaden II | - | FC Memmingen | 2:2 | ||||
| 7. Round | 12/09/2010 | SV Wehen Wiesbaden II | - | SG Sonnenhof Großaspach | 1:3 | ||||
| 9. Round | 22/09/2010 | SV Wehen Wiesbaden II | - | Stuttgarter Kickers | 1:3 | ||||
| 10. Round | 25/09/2010 | 1. FC Nürnberg II | - | SV Wehen Wiesbaden II | 2:0 | ||||
| 11. Round | 03/10/2010 | SV Wehen Wiesbaden II | - | 1899 Hoffenheim II | 2:5 | ||||
| 17. Round | 20/11/2010 | Karlsruher SC II | - | SV Wehen Wiesbaden II | 1:0 |  |
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| 18. Round | 28/11/2010 | SV Wehen Wiesbaden II | - | Eintracht Frankfurt II | 1:0 |
Germany
Eritrea