| 6. Round | 30/10/2021 | Bayer Leverkusen [Youth B] | - | SV Lippstadt 08 [Youth B] | 2:0 | ||||
| 8. Round | 28/11/2021 | SV Lippstadt 08 [Youth B] | - | VfL Bochum [Youth B] | 1:9 | ||||
| 9. Round | 13/02/2022 | Preußen Münster [Youth B] | - | SV Lippstadt 08 [Youth B] | 3:0 | ||||
| 11. Round | 20/02/2022 | Fortuna Köln [Youth B] | - | SV Lippstadt 08 [Youth B] | 3:1 | ||||
| 13. Round | 06/03/2022 | FC Schalke 04 [Youth B] | - | SV Lippstadt 08 [Youth B] | 5:0 |  |
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| 14. Round | 13/03/2022 | SV Lippstadt 08 [Youth B] | - | SC Paderborn 07 [Youth B] | 0:1 | ||||
| 12. Round | 30/03/2022 | SV Lippstadt 08 [Youth B] | - | FC Hennef 05 [Youth B] | 3:0 |  |
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| 15. Round | 02/04/2022 | Rot-Weiss Essen [Youth B] | - | SV Lippstadt 08 [Youth B] | 0:3 | |
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| 16. Round | 09/04/2022 | 1. FC Köln [Youth B] | - | SV Lippstadt 08 [Youth B] | 5:1 |
Germany