| 1. Round | 24/07/2021 | ASV Cham | - | ATSV Erlangen | 0:2 | ||||
| 2. Round | 28/07/2021 | DJK Ammerthal | - | ASV Cham | 2:2 | ||||
| 3. Round | 31/07/2021 | ASV Cham | - | Vatan Spor Aschaffenburg | 4:0 | ||||
| 4. Round | 04/08/2021 | ASV Cham | - | DJK Vilzing | 0:4 | ||||
| 5. Round | 07/08/2021 | ASV Cham | - | TSV Karlburg | 0:1 | ||||
| 6. Round | 14/08/2021 | ASV Neumarkt | - | ASV Cham | 4:1 | ||||
| 7. Round | 18/08/2021 | ASV Cham | - | Eintracht Bamberg | 0:4 | ||||
| 8. Round | 22/08/2021 | DJK Bamberg | - | ASV Cham | 1:0 | ||||
| 9. Round | 28/08/2021 | ASV Cham | - | 1. FC Sand | 1:1 | ||||
| 10. Round | 04/09/2021 | SpVgg Bayern Hof | - | ASV Cham | 7:2 | ||||
| 11. Round | 11/09/2021 | ASV Cham | - | SV Seligenporten | 4:1 | ||||
| 12. Round | 18/09/2021 | TSV Großbardorf | - | ASV Cham | 5:1 | ||||
| 13. Round | 25/09/2021 | ASV Cham | - | TSV Abtswind | 1:2 | ||||
| 14. Round | 02/10/2021 | Würzburger FV | - | ASV Cham | 1:0 | ||||
| 16. Round | 16/10/2021 | ASV Cham | - | SpVgg Ansbach | 2:2 | ||||
| 17. Round | 22/10/2021 | DJK Gebenbach | - | ASV Cham | 4:1 | ||||
| 18. Round | 29/10/2021 | ATSV Erlangen | - | ASV Cham | 5:1 | ||||
| 19. Round | 06/11/2021 | ASV Cham | - | DJK Ammerthal | 0:1 | ||||
| 20. Round | 13/11/2021 | Vatan Spor Aschaffenburg | - | ASV Cham | 2:1 |
Czech Republic