| 1. Round | 30/08/1980 | TSG Bau Rostock | - | TSG Wismar | 4:1 | ||||
| 2. Round | 06/09/1980 | TSG Wismar | - | SG Dynamo Schwerin | 1:3 | ||||
| 3. Round | 13/09/1980 | BSG Post Neubrandenburg | - | TSG Wismar | 6:1 | ||||
| 4. Round | 20/09/1980 | TSG Wismar | - | Chemie/Motor Veritas Wittenberge | 1:1 | ||||
| 5. Round | 04/10/1980 | BSG Lok Anklam | - | TSG Wismar | 1:1 |  |
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| 6. Round | 07/10/1980 | TSG Wismar | - | ASG Vorwärts Stralsund | 0:0 | ||||
| 7. Round | 19/10/1980 | BSG Schiffahrt/Hafen Rostock | - | TSG Wismar | 4:2 | |
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| 8. Round | 26/10/1980 | TSG Wismar | - | ISG Schwerin | 3:2 | ||||
| 9. Round | 08/11/1980 | ASG Vorwärts Neubrandenburg | - | TSG Wismar | 1:2 | ||||
| 10. Round | 15/11/1980 | BSG KKW Greifswald | - | TSG Wismar | 3:3 | |
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| 12. Round | 29/11/1980 | TSG Wismar | - | TSG Bau Rostock | 3:2 | ||||
| 13. Round | 06/12/1980 | SG Dynamo Schwerin | - | TSG Wismar | 1:1 | ||||
| 14. Round | 12/12/1980 | TSG Wismar | - | BSG Post Neubrandenburg | 1:2 | ||||
| 15. Round | 28/02/1981 | Chemie/Motor Veritas Wittenberge | - | TSG Wismar | 3:4 | |
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| 16. Round | 07/03/1981 | TSG Wismar | - | BSG Lok Anklam | 2:0 | |
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| 17. Round | 14/03/1981 | ASG Vorwärts Stralsund | - | TSG Wismar | 2:0 |
Germany