| 2. Round | 03/09/2021 | RSV Meinerzhagen | - | FCE Rheine | 1:2 |  |
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| 3. Round | 12/09/2021 | TSG Sprockhövel | - | RSV Meinerzhagen | 6:1 | ||||
| 4. Round | 19/09/2021 | RSV Meinerzhagen | - | Hammer SpVg | 2:0 | ||||
| 6. Round | 03/10/2021 | RSV Meinerzhagen | - | SpVgg Vreden | 0:1 | ||||
| 7. Round | 10/10/2021 | FC Gütersloh | - | RSV Meinerzhagen | 3:0 | ||||
| 9. Round | 24/10/2021 | TuS Erndtebrück | - | RSV Meinerzhagen | 1:0 | ||||
| 10. Round | 31/10/2021 | RSV Meinerzhagen | - | Preußen Münster II | 2:1 | ||||
| 13. Round | 20/11/2021 | RSV Meinerzhagen | - | Westfalia Herne | 4:2 | ||||
| 14. Round | 28/11/2021 | Westfalia Rhynern | - | RSV Meinerzhagen | 6:0 | ||||
| 15. Round | 05/12/2021 | RSV Meinerzhagen | - | Holzwickeder SC | 4:1 | ||||
| 11. Round | 08/12/2021 | SC Paderborn 07 II | - | RSV Meinerzhagen | 5:1 | ||||
| 16. Round | 11/12/2021 | ASC 09 Dortmund | - | RSV Meinerzhagen | 4:3 |
Germany