| 21. Round | 27/01/2012 | Sportfreunde Lotte | - | FC Schalke 04 II | 2:0 | ||||
| 25. Round | 24/02/2012 | Sportfreunde Lotte | - | 1. FSV Mainz 05 II | 1:0 | ||||
| 26. Round | 03/03/2012 | 1. FC Köln II | - | Sportfreunde Lotte | 1:1 | ||||
| 27. Round | 10/03/2012 | Sportfreunde Lotte | - | SV 07 Elversberg | 4:3 | ||||
| 29. Round | 24/03/2012 | Sportfreunde Lotte | - | SC Verl | 2:1 | ||||
| 20. Round | 28/03/2012 | SC 07 Idar-Oberstein | - | Sportfreunde Lotte | 1:1 | ||||
| 30. Round | 31/03/2012 | Bor. Mönchengladbach II | - | Sportfreunde Lotte | 0:2 |  |
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| 31. Round | 08/04/2012 | Sportfreunde Lotte | - | Rot-Weiss Essen | 1:1 | ||||
| 32. Round | 11/04/2012 | VfL Bochum II | - | Sportfreunde Lotte | 0:2 | |
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| 33. Round | 14/04/2012 | Sportfreunde Lotte | - | Wuppertaler SV | 3:5 | ||||
| 34. Round | 21/04/2012 | 1. FC Kaiserslautern II | - | Sportfreunde Lotte | 0:1 | |
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| 35. Round | 27/04/2012 | Sportfreunde Lotte | - | Bayer Leverkusen II | 2:0 | |
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| 37. Round | 11/05/2012 | Eintracht Trier | - | Sportfreunde Lotte | 0:1 | ||||
| 38. Round | 19/05/2012 | Sportfreunde Lotte | - | SC Wiedenbrück | 2:1 |
Germany