| 5. Round | 18/09/2021 | 1. FC Union Berlin [Youth B] | - | RB Leipzig [Youth B] | 3:0 | ||||
| 6. Round | 25/09/2021 | RB Leipzig [Youth B] | - | Hannover 96 [Youth B] | 1:3 | ||||
| 7. Round | 02/10/2021 | Dynamo Dresden [Youth B] | - | RB Leipzig [Youth B] | 1:2 | ||||
| 8. Round | 09/10/2021 | RB Leipzig [Youth B] | - | FC Viktoria 1889 Berlin [Youth B] | 2:3 | ||||
| 15. Round | 05/03/2022 | RB Leipzig [Youth B] | - | Eintracht Braunschweig [Youth B] | 3:0 | ||||
| 11. Round | 08/03/2022 | RB Leipzig [Youth B] | - | FC St. Pauli [Youth B] | 1:2 | ||||
| 16. Round | 13/03/2022 | Werder Bremen [Youth B] | - | RB Leipzig [Youth B] | 2:3 | ||||
| 17. Round | 03/04/2022 | RB Leipzig [Youth B] | - | Holstein Kiel [Youth B] | 3:2 | ||||
| 18. Round | 09/04/2022 | Hamburger SV [Youth B] | - | RB Leipzig [Youth B] | 1:2 | ||||
| 19. Round | 23/04/2022 | RB Leipzig [Youth B] | - | Hertha Zehlendorf [Youth B] | 2:1 |
Germany