| 1. Round | 22/08/2021 | SpVg Schonnebeck | - | Schwarz-Weiß Essen | 5:0 | ||||
| 4. Round | 12/09/2021 | TuRU Düsseldorf | - | SpVg Schonnebeck | 3:3 | ||||
| 5. Round | 19/09/2021 | SpVg Schonnebeck | - | Germania Ratingen 04/19 | 0:2 | ||||
| 6. Round | 26/09/2021 | 1. FC Monheim | - | SpVg Schonnebeck | 1:1 | ||||
| 10. Round | 24/10/2021 | SC Velbert | - | SpVg Schonnebeck | 1:3 | ||||
| 11. Round | 31/10/2021 | SpVg Schonnebeck | - | Sportfreunde Niederwenigern | 2:2 | ||||
| 12. Round | 07/11/2021 | TV Jahn Hiesfeld | - | SpVg Schonnebeck | 0:3 | ||||
| 14. Round | 28/11/2021 | SpVg Schonnebeck | - | Cronenberger SC | 3:1 | ||||
| 15. Round | 04/12/2021 | SC Union Nettetal | - | SpVg Schonnebeck | 1:0 |  |
Germany