| 1. Round | 04/08/1980 | 1. FC Saarbrücken | - | VfR Bürstadt | 0:2 |  |
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| 2. Round | 08/08/1980 | VfR Bürstadt | - | FC 08 Homburg | 3:1 | |
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| 3. Round | 15/08/1980 | Wormatia Worms | - | VfR Bürstadt | 1:2 | |
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| 4. Round | 19/08/1980 | VfR Bürstadt | - | FSV Frankfurt | 0:1 |  |
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| 5. Round | 22/08/1980 | SV Darmstadt 98 | - | VfR Bürstadt | 5:0 | ||||
| 6. Round | 28/08/1980 | VfR Bürstadt | - | SC Freiburg | 1:1 | ||||
| 24. Round | 06/02/1981 | VfR Bürstadt | - | SV Darmstadt 98 | 1:1 | ||||
| 22. Round | 20/02/1981 | VfR Bürstadt | - | Wormatia Worms | 1:1 | |
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| 26. Round | 20/02/1981 | VfR Bürstadt | - | Hessen Kassel | 2:0 | ||||
| 27. Round | 05/03/1981 | FC Augsburg | - | VfR Bürstadt | 1:2 | ||||
| 28. Round | 12/03/1981 | VfR Bürstadt | - | VfB Eppingen | 2:1 | ||||
| 30. Round | 26/03/1981 | VfR Bürstadt | - | Borussia Neunkirchen | 4:1 | ||||
| 33. Round | 14/04/1981 | VfR Bürstadt | - | ESV Ingolstadt | 1:2 | ||||
| 34. Round | 23/04/1981 | Kickers Offenbach | - | VfR Bürstadt | 6:1 | ||||
| 38. Round | 29/05/1981 | SpVgg Fürth | - | VfR Bürstadt | 0:1 |
Germany